From: History of Vernon County, Missouri. 1887, p. 800.

Dr. Holmes, whose career thus far in life has been one unmarked by any especial event of startling importance, has nevertheless pursued a course both honorable and successful, and one that stamps him professionally of stirring energy and determination to succeed. He was horn August 15, 1855, in Johnson County, Mo., his parents being Benjamin A. Holmes and wife, Sarah A. The father was of sturdy Virginia nativity and reared all his children, and he had nine, to habits of industry and intelligent application to the different duties which they chose to follow. Frank turned his attention towards a professional life, and after due preparation and fitness for the calling he commenced the practice of medicine in 1881, when he came to this county. During the several years’ residence in this locality he has built up a reputation for skill and ability which has rendered him well known. The numerous calls made upon him for professional service carries him over a wide territory and secure for him a large acquaintance, which he well merits. The Doctor is a married man, Miss Anna A. Huffman having assumed his name some years ago. Her father, Adam Huffman, was one of the early settlers of Missouri, and at present is a resident of Garland, Kan.